EPYC 75F3 vs EPYC 7543

AMD

EPYC 75F3

32 Cores64 Thrd280 WWMax: 4 GHz2021

Popular choices:

VS
AMD

EPYC 7543

32 Cores64 Thrd225 WWMax: 3.7 GHz2021

Popular choices:

Performance Spectrum - CPU

About PassMark

PassMark CPU Mark evaluates processor speed through complex mathematical computations. It provides a reliable metric to compare multi-core performance, where higher scores indicate faster processing for multitasking, gaming, and heavy workloads.

Head-to-Head Verdict, Benchmarks, Value & Long-Term Outlook

This comparison brings together gaming FPS, productivity performance, platform differences, power efficiency, pricing context, and upgrade path so you can see which CPU actually makes more sense.

EPYC 75F3

2021

Why buy it

  • Better for gaming: +5.2% higher average FPS across 4 shared CPU benchmark tests.
  • Costs $4,874 less on MSRP ($5,383 MSRP vs $10,257 MSRP).
  • Delivers 95.2% more PassMark for each dollar spent, at 12.0 vs 6.1 PassMark/$ ($5,383 MSRP vs $10,257 MSRP).

Trade-offs

  • 24.4% higher power demand at 280W vs 225W.

EPYC 7543

2021

Why buy it

  • Draws 225W instead of 280W, a 55W reduction.

Trade-offs

  • Worse for gaming: lower average FPS than EPYC 75F3 across 4 shared CPU benchmark tests.
  • Lower PassMark (62,952 vs 64,505).
  • Lower PassMark per dollar, at 6.1 vs 12.0 PassMark/$ ($10,257 MSRP vs $5,383 MSRP).

Quick Answers

So, is EPYC 75F3 better than EPYC 7543?
Yes. EPYC 75F3 is the better overall CPU here. You are getting a 5.2% average FPS lead across 4 shared CPU game tests in our data, 2.5% better PassMark, and the stronger long-term platform, which makes it the stronger all-around choice.
Which one is better for gaming?
If gaming is the priority, EPYC 75F3 is the better pick here. According to our tests, it delivers 5.2% more average FPS across 4 shared CPU game tests.
Which one is better for streaming, content creation, and heavy multitasking?
For streaming, content creation, and heavier multitasking, EPYC 75F3 is the better fit. You are getting 2.5% better PassMark, backed by 32 cores and 64 threads.
Which one is the smarter buy today, not just the cheaper CPU?
EPYC 75F3 is the smarter buy today. EPYC 75F3 is $4,874 cheaper on MSRP at $5,383 MSRP versus $10,257 MSRP, and it gives you a 5.2% average FPS lead across 4 shared CPU game tests in our data. It is also 95.2% better value on MSRP (12.0 vs 6.1 PassMark/$), so the better CPU is not just faster, it is also the cleaner value play on paper.
Which one is more future-proof for 2026 and beyond?
EPYC 75F3 is the more future-proof choice for 2026 and beyond. You are getting more multi-core headroom with 32 cores / 64 threads instead of 32/64. That extra cache should hold up really well in CPU-limited games and high-refresh builds.

Games Benchmarks

Paired with RTX 4090

To accurately isolate CPU performance, all benchmarks below use an NVIDIA RTX 4090 as the reference GPU. This eliminates GPU-side bottlenecks and highlights pure processing throughput differences between the CPUs.

Note: Real-world results may vary based on your actual GPU. CPU performance impact is more visible in processing-intensive titles and high-refresh-rate gaming scenarios.

Path of Exile 2

Path of Exile 2

PresetEPYC 75F3EPYC 7543
1080p
low198 FPS198 FPS
medium161 FPS161 FPS
high130 FPS129 FPS
ultra100 FPS100 FPS
1440p
low162 FPS161 FPS
medium126 FPS126 FPS
high98 FPS98 FPS
ultra78 FPS78 FPS
4K
low73 FPS73 FPS
medium61 FPS61 FPS
high47 FPS47 FPS
ultra39 FPS39 FPS
Counter-Strike 2

Counter-Strike 2

PresetEPYC 75F3EPYC 7543
1080p
low507 FPS507 FPS
medium443 FPS443 FPS
high354 FPS354 FPS
ultra288 FPS288 FPS
1440p
low417 FPS417 FPS
medium373 FPS373 FPS
high308 FPS308 FPS
ultra243 FPS243 FPS
4K
low257 FPS257 FPS
medium234 FPS234 FPS
high205 FPS205 FPS
ultra171 FPS171 FPS
League of Legends

League of Legends

PresetEPYC 75F3EPYC 7543
1080p
low948 FPS850 FPS
medium792 FPS705 FPS
high734 FPS657 FPS
ultra657 FPS580 FPS
1440p
low661 FPS612 FPS
medium552 FPS506 FPS
high503 FPS464 FPS
ultra442 FPS405 FPS
4K
low472 FPS437 FPS
medium374 FPS339 FPS
high330 FPS303 FPS
ultra268 FPS245 FPS
Valorant

Valorant

PresetEPYC 75F3EPYC 7543
1080p
low1006 FPS992 FPS
medium908 FPS900 FPS
high782 FPS775 FPS
ultra679 FPS671 FPS
1440p
low770 FPS763 FPS
medium671 FPS665 FPS
high575 FPS569 FPS
ultra500 FPS490 FPS
4K
low556 FPS547 FPS
medium495 FPS488 FPS
high435 FPS428 FPS
ultra374 FPS370 FPS

Technical Specifications

Side-by-side comparison of EPYC 75F3 and EPYC 7543

AMD

EPYC 75F3

The EPYC 75F3 is manufactured by AMD. It was released in 15 March 2021 (4 years ago). It is based on the Milan (2021−2023) architecture. It features 32 cores and 64 threads. Base frequency is 2.95 GHz, with boost up to 4 GHz. L3 cache: 256 MB (total). L2 cache: 512 kB (per core). Built on 7 nm+ process technology. Socket: SP3. Thermal design power (TDP): 280 Watt. Memory support: DDR4-3200. Passmark benchmark score: 64,505 points. Launch price was $4,860.

AMD

EPYC 7543

The EPYC 7543 is manufactured by AMD. It was released in 15 March 2021 (4 years ago). It is based on the Milan (2021−2023) architecture. It features 32 cores and 64 threads. Base frequency is 2.8 GHz, with boost up to 3.7 GHz. L3 cache: 256 MB (total). L2 cache: 512 kB (per core). Built on 7 nm+ process technology. Socket: SP3. Thermal design power (TDP): 225 Watt. Memory support: DDR4-3200. Passmark benchmark score: 62,952 points. Launch price was $3,761.

Processing Power

Both the EPYC 75F3 and EPYC 7543 share an identical 32-core/64-thread configuration. Boost clocks reach 4 GHz on the EPYC 75F3 versus 3.7 GHz on the EPYC 7543 — a 7.8% clock advantage for the EPYC 75F3 (base: 2.95 GHz vs 2.8 GHz). Both are built on the Milan (2021−2023) architecture using a 7 nm+ process. In PassMark, the EPYC 75F3 scores 64,505 against the EPYC 7543's 62,952 — a 2.4% lead for the EPYC 75F3. Both processors carry 256 MB (total) of L3 cache.

FeatureEPYC 75F3EPYC 7543
Cores / Threads
32 / 64
32 / 64
Boost Clock
4 GHz+8%
3.7 GHz
Base Clock
2.95 GHz+5%
2.8 GHz
L3 Cache
256 MB (total)
256 MB (total)
L2 Cache
512 kB (per core)
512 kB (per core)
Process
7 nm+
7 nm+
Architecture
Milan (2021−2023)
Milan (2021−2023)
PassMark
64,505+2%
62,952
🧠

Memory & Platform

Both processors use the SP3 socket with PCIe 4.0. Both support up to 3200 memory speed. Both support up to 4096 of RAM. Both feature 8-channel memory with ECC support. Both provide 128 PCIe lanes. Chipset compatibility: SP3 (EPYC 75F3) and SP3 (EPYC 7543).

FeatureEPYC 75F3EPYC 7543
Socket
SP3
SP3
PCIe Generation
PCIe 4.0
PCIe 4.0
Max RAM Speed
3200
3200
Max RAM Capacity
4096
4096
RAM Channels
8
8
ECC Support
Yes
Yes
PCIe Lanes
128
128
🔧

Advanced Features

Neither processor supports overclocking. Both support VT-x, VT-d virtualization. Direct competitor: EPYC 75F3 rivals Xeon Platinum 8380; EPYC 7543 rivals Xeon Platinum 8380.

FeatureEPYC 75F3EPYC 7543
Integrated GPU
No
No
IGPU Model
None
None
Unlocked
No
No
AVX-512
No
No
Virtualization
VT-x, VT-d
VT-x, VT-d
💰

Value Analysis

The EPYC 75F3 launched at $5383 MSRP, while the EPYC 7543 debuted at $10257. On MSRP ($5383 vs $10257), the EPYC 75F3 is $4874 cheaper. In terms of value on MSRP (PassMark points per dollar), the EPYC 75F3 delivers 12.0 pts/$ vs 6.1 pts/$ for the EPYC 7543 — making the EPYC 75F3 the 64.5% better value option.

FeatureEPYC 75F3EPYC 7543
MSRP
$5383-48%
$10257
Performance per Dollar
12.0+97%
6.1
Release Date
2021
2021