Quadro GP100 vs Radeon Pro Vega 64X

NVIDIA

Quadro GP100

2016Core: 1304 MHzBoost: 1442 MHz

Popular choices:

VS
AMD

Radeon Pro Vega 64X

2019Core: 1250 MHzBoost: 1468 MHz

Popular choices:

Performance Spectrum - GPU

About G3D Mark

G3D Mark is a standard benchmark that measures graphics performance in real-world gaming scenarios. It simplifies comparing cards from different brands, where higher scores directly correlate with better fps and smoother gaming experiences.

Head-to-Head Verdict, Benchmarks, Value & Long-Term Outlook

This comparison brings together gaming FPS, raw graphics performance, VRAM, feature set, power efficiency, pricing context, and long-term value so you can see which GPU actually makes more sense.

Quadro GP100

2016

Why buy it

  • 43.0% more average FPS across 48 tracked games in our benchmark data.
  • 100+% more VRAM for high-resolution textures and newer games (16 GB vs Unknown).
  • Less risky long-term buy than Radeon Pro Vega 64X: it remains the more sensible modern option while Radeon Pro Vega 64X is already legacy-tier future-proofing.

Trade-offs

  • Poor future-proofing: 2016-era hardware with 16 GB of VRAM is already a legacy-tier option for modern games.
  • 218.2% HIGHER MSRP
    $7,000 MSRPvs$2,200 MSRP
  • Lower G3D Mark per dollar, at 2.0 vs 6.1 G3D/$ ($7,000 MSRP vs $2,200 MSRP).

Radeon Pro Vega 64X

2019

Why buy it

  • Costs $4,800 less on MSRP ($2,200 MSRP vs $7,000 MSRP).
  • Delivers 210.3% more G3D Mark for each dollar spent, at 6.1 vs 2.0 G3D/$ ($2,200 MSRP vs $7,000 MSRP).
  • More future proof: GCN 5.0 (2017−2020) on 14nm with a newer platform for upcoming games.

Trade-offs

  • Lower average FPS than Quadro GP100 across 48 tracked games in our benchmark data.
  • Less VRAM, with Unknown vs 16 GB for high-resolution textures and newer games.
  • Poor future-proofing: 2019-era hardware with Unknown of VRAM is already a legacy-tier option for modern games.

Quick Answers

So, is Quadro GP100 better than Radeon Pro Vega 64X?
Yes. Quadro GP100 is the better GPU overall here. You are getting 43.0% more average FPS across 48 tracked games in our benchmark data, 2.6% higher PassMark G3D performance, and 16 GB vs Unknown of VRAM. It also comes from 2016 instead of 2019, which helps its case as the more complete modern gaming card.
Which one is more future-proof for 2026 and beyond?
Quadro GP100 is the more future-proof choice for 2026 and beyond. You are getting more VRAM at 16 GB instead of Unknown and the stronger feature stack with no meaningful modern upscaling stack instead of FSR upscaling. That extra memory headroom makes it the safer pick for newer games, heavier textures, and higher settings over time.
Which one is the smarter buy today, not just the cheaper card?
Quadro GP100 is the smarter buy by a wide margin. Quadro GP100 is about 218.2% more expensive on MSRP at $7,000 MSRP versus $2,200 MSRP, and you are getting 43.0% more estimated average FPS across 48 tracked games in our benchmark data and 2.6% higher G3D Mark. Radeon Pro Vega 64X really only makes sense now as a very cheap stopgap or a used-market placeholder.
When does Radeon Pro Vega 64X make more sense than Quadro GP100?
Yes. Radeon Pro Vega 64X is still an excellent gaming GPU in 2026: it is very strong for 1080p, good for 1440p, and more limited at 4K. It makes more sense if your priority is newer architecture and staying closer to $2,200 MSRP more than squeezing out the extra headroom of Quadro GP100. The trade-off is that Quadro GP100 currently gives you 2.6% higher G3D Mark and 43.0% more estimated average FPS across 48 tracked games in our benchmark data. Radeon Pro Vega 64X still holds the G3D-per-dollar lead, so the performance win comes with a real value premium.

Games Benchmarks

Real-world benchmarks and performance projections based on comprehensive hardware analysis and comparative metrics. Values represent expected performance on High/Ultra settings at 1080p, 1440p, and 4K. Modeled using a Ryzen 7 9800X3D reference profile to minimize specific CPU bottlenecks.

Note: Performance behavior can vary per game. Specific architectures may perform better or worse depending on game engine optimizations and API implementation.

Path of Exile 2

Path of Exile 2

PresetQuadro GP100Radeon Pro Vega 64X
1080p
low190 FPS108 FPS
medium177 FPS98 FPS
high152 FPS83 FPS
ultra138 FPS69 FPS
1440p
low177 FPS96 FPS
medium149 FPS82 FPS
high118 FPS66 FPS
ultra108 FPS56 FPS
4K
low109 FPS48 FPS
medium91 FPS43 FPS
high67 FPS33 FPS
ultra61 FPS29 FPS
Counter-Strike 2

Counter-Strike 2

PresetQuadro GP100Radeon Pro Vega 64X
1080p
low313 FPS301 FPS
medium274 FPS262 FPS
high207 FPS203 FPS
ultra171 FPS164 FPS
1440p
low212 FPS204 FPS
medium181 FPS175 FPS
high145 FPS144 FPS
ultra118 FPS114 FPS
4K
low108 FPS100 FPS
medium91 FPS84 FPS
high75 FPS71 FPS
ultra59 FPS56 FPS
League of Legends

League of Legends

PresetQuadro GP100Radeon Pro Vega 64X
1080p
low617 FPS526 FPS
medium494 FPS452 FPS
high411 FPS383 FPS
ultra308 FPS301 FPS
1440p
low463 FPS413 FPS
medium370 FPS347 FPS
high308 FPS296 FPS
ultra231 FPS226 FPS
4K
low308 FPS258 FPS
medium247 FPS214 FPS
high206 FPS173 FPS
ultra154 FPS135 FPS
Valorant

Valorant

PresetQuadro GP100Radeon Pro Vega 64X
1080p
low455 FPS258 FPS
medium417 FPS213 FPS
high334 FPS180 FPS
ultra286 FPS151 FPS
1440p
low365 FPS197 FPS
medium337 FPS162 FPS
high259 FPS133 FPS
ultra218 FPS112 FPS
4K
low234 FPS118 FPS
medium218 FPS105 FPS
high177 FPS85 FPS
ultra146 FPS70 FPS

Technical Specifications

Side-by-side comparison of Quadro GP100 and Radeon Pro Vega 64X

NVIDIA

Quadro GP100

The Quadro GP100 is manufactured by NVIDIA. It was released in October 1 2016. It features the Pascal architecture. The core clock ranges from 1304 MHz to 1442 MHz. It has 3584 shading units. The thermal design power (TDP) is 235W. Manufactured using 16 nm process technology. G3D Mark benchmark score: 13,710 points.

AMD

Radeon Pro Vega 64X

The Radeon Pro Vega 64X is manufactured by AMD. It was released in March 19 2019. It features the GCN 5.0 architecture. The core clock ranges from 1250 MHz to 1468 MHz. It has 4096 shading units. The thermal design power (TDP) is 250W. Manufactured using 14 nm process technology. G3D Mark benchmark score: 13,369 points.

Graphics Performance

The Quadro GP100 scores 13,710 and the Radeon Pro Vega 64X reaches 13,369 in the G3D Mark benchmark — just a 2.6% difference, making them near-identical in rasterization performance. The Quadro GP100 is built on Pascal while the Radeon Pro Vega 64X uses GCN 5.0, both on 16 nm vs 14 nm. Shader units: 3,584 (Quadro GP100) vs 4,096 (Radeon Pro Vega 64X). Raw compute: 10.34 TFLOPS (Quadro GP100) vs 12.03 TFLOPS (Radeon Pro Vega 64X). Boost clocks: 1442 MHz vs 1468 MHz.

FeatureQuadro GP100Radeon Pro Vega 64X
G3D Mark Score
13,710+3%
13,369
Architecture
Pascal
GCN 5.0
Process Node
16 nm
14 nm
Shading Units
3584
4096+14%
Compute (TFLOPS)
10.34 TFLOPS
12.03 TFLOPS+16%
Boost Clock
1442 MHz
1468 MHz+2%
ROPs
96+50%
64
TMUs
224
256+14%
L1 Cache
1.3 MB+30%
1 MB
L2 Cache
4 MB
4 MB

Advanced Features (DLSS/FSR)

FeatureQuadro GP100Radeon Pro Vega 64X
Upscaling Tech
Upscaling support
FSR Upscaling / FSR 4
Frame Generation
Not Supported
Not Supported
Ray Reconstruction
No
No
Low Latency
Standard
AMD Anti-Lag
💾

Video Memory (VRAM)

The Quadro GP100 comes with 16 GB of VRAM, while the Radeon Pro Vega 64X has 0 MB. The Quadro GP100 offers 100+% more capacity, crucial for higher resolutions and texture-heavy games. Bus width: 4096-bit vs 128-bit.

FeatureQuadro GP100Radeon Pro Vega 64X
VRAM Capacity
16 GB
Shared System RAM
Memory Type
HBM2
GDDR6
Bus Width
4096-bit+3100%
128-bit
L2 Cache
4 MB
4 MB
🖥️

Display & API Support

DirectX support: 12 (Quadro GP100) vs 12.1 (Radeon Pro Vega 64X). Vulkan: 1.3 vs 1.1. OpenGL: 4.5 vs 4.6. Maximum simultaneous displays: 4 vs 4.

FeatureQuadro GP100Radeon Pro Vega 64X
DirectX
12
12.1
Vulkan
1.3+18%
1.1
OpenGL
4.5
4.6+2%
Max Displays
4
4
🎬

Media & Encoding

Hardware encoder: NVENC 4th gen (Quadro GP100) vs VCE 4.0 (Radeon Pro Vega 64X). Decoder: NVDEC 3rd gen vs UVD 7.0. Supported codecs: H.264,H.265/HEVC,MPEG-2,VC-1,VP8,VP9 (Quadro GP100) vs MPEG-2,H.264,HEVC,VP9 (Radeon Pro Vega 64X).

FeatureQuadro GP100Radeon Pro Vega 64X
Encoder
NVENC 4th gen
VCE 4.0
Decoder
NVDEC 3rd gen
UVD 7.0
Codecs
H.264,H.265/HEVC,MPEG-2,VC-1,VP8,VP9
MPEG-2,H.264,HEVC,VP9
🔌

Power & Dimensions

The Quadro GP100 draws 235W versus the Radeon Pro Vega 64X's 250W — a 6.2% difference. The Quadro GP100 is more power-efficient. Recommended PSU: 500W (Quadro GP100) vs 1W (Radeon Pro Vega 64X). Power connectors: PCIe-powered vs Integrated. Card length: 267mm vs 0mm, occupying 2 vs 0 slots. Typical load temperature: 80°C vs 85°C.

FeatureQuadro GP100Radeon Pro Vega 64X
TDP
235W-6%
250W
Recommended PSU
500W
1W-100%
Power Connector
PCIe-powered
Integrated
Length
267mm
0mm
Height
111mm
0mm
Slots
2
0-100%
Temp (Load)
80°C-6%
85°C
Perf/Watt
58.3+9%
53.5
💰

Value Analysis

The Quadro GP100 launched at $7000 MSRP, while the Radeon Pro Vega 64X launched at $2200. The Radeon Pro Vega 64X costs 68.6% less ($4800 savings) on MSRP. Performance per dollar on MSRP (G3D Mark / MSRP): 2.0 (Quadro GP100) vs 6.1 (Radeon Pro Vega 64X) — the Radeon Pro Vega 64X offers 205% better value. The Radeon Pro Vega 64X is the newer GPU (2019 vs 2016).

FeatureQuadro GP100Radeon Pro Vega 64X
MSRP
$7000
$2200-69%
Performance per Dollar
2.0
6.1+205%
Codename
GP100
Vega 10
Release
October 1 2016
March 19 2019
Ranking
#178
#190