Quadro M5500 vs Radeon RX 6400

NVIDIA

Quadro M5500

2016Core: 1140 MHzBoost: 1165 MHz

Popular choices:

VS
AMD

Radeon RX 6400

2022Core: 1923 MHzBoost: 2321 MHz

Popular choices:

Performance Spectrum - GPU

About G3D Mark

G3D Mark is a standard benchmark that measures graphics performance in real-world gaming scenarios. It simplifies comparing cards from different brands, where higher scores directly correlate with better fps and smoother gaming experiences.

Head-to-Head Verdict, Benchmarks, Value & Long-Term Outlook

This comparison brings together gaming FPS, raw graphics performance, VRAM, feature set, power efficiency, pricing context, and long-term value so you can see which GPU actually makes more sense.

Quadro M5500

2016

Why buy it

  • 59.9% more average FPS across 50 tracked games in our benchmark data.
  • 100% more VRAM for high-resolution textures and newer games (8 GB vs 4 GB).

Trade-offs

  • No equivalent frame-generation stack like FSR Frame Generation + AFMF (2023).
  • Poor future-proofing: 2016-era hardware with 8 GB of VRAM is already a legacy-tier option for modern games.
  • 403.1% HIGHER MSRP
    $800 MSRPvs$159 MSRP
  • Lower G3D Mark per dollar, at 9.9 vs 48.6 G3D/$ ($800 MSRP vs $159 MSRP).
  • 183% higher power demand at 150W vs 53W.

Radeon RX 6400

2022

Why buy it

  • Costs $641 less on MSRP ($159 MSRP vs $800 MSRP).
  • Delivers 391.3% more G3D Mark for each dollar spent, at 48.6 vs 9.9 G3D/$ ($159 MSRP vs $800 MSRP).
  • Access to a newer frame-generation stack with FSR Frame Generation + AFMF (2023).
  • More future proof: RDNA 2.0 (2020−2025) on 6nm with a newer platform for upcoming games.
  • Draws 53W instead of 150W, a 97W reduction.

Trade-offs

  • Lower average FPS than Quadro M5500 across 50 tracked games in our benchmark data.
  • Less VRAM, with 4 GB vs 8 GB for high-resolution textures and newer games.

Quick Answers

So, is Quadro M5500 better than Radeon RX 6400?
Yes. Quadro M5500 is clearly the better overall GPU here. Quadro M5500 averages 59.9% more FPS across 50 tracked games in our benchmark data. You are also looking at 7,915 vs 7,728 in G3D Mark. On top of that, Quadro M5500 is a 2016 card with no meaningful modern upscaling stack, while Radeon RX 6400 is a 2022 model from an older generation with FSR 3 + AFMF. So this is not really a tight same-tier comparison. It is more a modern card against an older, weaker alternative.
Which one is more future-proof for 2026 and beyond?
Radeon RX 6400 is the more future-proof choice for 2026 and beyond. You are getting a newer 2022 generation instead of 2016, better upscaling support with FSR 3 (2023) instead of no meaningful modern upscaling stack and better frame-generation support with FSR Frame Generation + AFMF (2023) instead of no meaningful modern upscaling stack, and a 6nm process instead of 28nm. That broader feature stack should age better as more games lean on modern upscaling and frame-generation support.
Which one is the smarter buy today, not just the cheaper card?
Quadro M5500 is the smarter buy by a wide margin. Quadro M5500 is about 403.1% more expensive on MSRP at $800 MSRP versus $159 MSRP, and you are getting 59.9% more estimated average FPS across 50 tracked games in our benchmark data and 2.4% higher G3D Mark. Radeon RX 6400 really only makes sense now as a very cheap stopgap or a used-market placeholder.
When does Radeon RX 6400 make more sense than Quadro M5500?
Yes. Radeon RX 6400 is still an excellent gaming GPU in 2026: it is still comfortable for 1080p and decent for 1440p, though 4K is more situational. It makes more sense if your priority is newer architecture, lower power draw (53W vs 150W), future-proofing, and staying closer to $159 MSRP more than squeezing out the extra headroom of Quadro M5500. The trade-off is that Quadro M5500 currently gives you 2.4% higher G3D Mark and 59.9% more estimated average FPS across 50 tracked games in our benchmark data. Radeon RX 6400 still holds the G3D-per-dollar lead, so the performance win comes with a real value premium.

Games Benchmarks

Real-world benchmarks and performance projections based on comprehensive hardware analysis and comparative metrics. Values represent expected performance on High/Ultra settings at 1080p, 1440p, and 4K. Modeled using a Ryzen 7 9800X3D reference profile to minimize specific CPU bottlenecks.

Note: Performance behavior can vary per game. Specific architectures may perform better or worse depending on game engine optimizations and API implementation.

Path of Exile 2

Path of Exile 2

PresetQuadro M5500Radeon RX 6400
1080p
low108 FPS104 FPS
medium91 FPS92 FPS
high78 FPS79 FPS
ultra52 FPS66 FPS
1440p
low92 FPS94 FPS
medium77 FPS80 FPS
high59 FPS67 FPS
ultra38 FPS56 FPS
4K
low36 FPS45 FPS
medium33 FPS42 FPS
high21 FPS31 FPS
ultra18 FPS28 FPS
Counter-Strike 2

Counter-Strike 2

PresetQuadro M5500Radeon RX 6400
1080p
low229 FPS158 FPS
medium198 FPS124 FPS
high151 FPS92 FPS
ultra120 FPS60 FPS
1440p
low170 FPS104 FPS
medium144 FPS81 FPS
high116 FPS60 FPS
ultra91 FPS42 FPS
4K
low98 FPS53 FPS
medium82 FPS41 FPS
high69 FPS33 FPS
ultra52 FPS20 FPS
League of Legends

League of Legends

PresetQuadro M5500Radeon RX 6400
1080p
low356 FPS329 FPS
medium285 FPS278 FPS
high237 FPS210 FPS
ultra178 FPS172 FPS
1440p
low267 FPS232 FPS
medium214 FPS208 FPS
high178 FPS156 FPS
ultra134 FPS121 FPS
4K
low178 FPS134 FPS
medium142 FPS121 FPS
high119 FPS82 FPS
ultra89 FPS54 FPS
Valorant

Valorant

PresetQuadro M5500Radeon RX 6400
1080p
low234 FPS251 FPS
medium202 FPS186 FPS
high164 FPS165 FPS
ultra140 FPS138 FPS
1440p
low183 FPS192 FPS
medium159 FPS139 FPS
high125 FPS126 FPS
ultra104 FPS101 FPS
4K
low100 FPS101 FPS
medium80 FPS74 FPS
high63 FPS65 FPS
ultra50 FPS50 FPS

Technical Specifications

Side-by-side comparison of Quadro M5500 and Radeon RX 6400

NVIDIA

Quadro M5500

The Quadro M5500 is manufactured by NVIDIA. It was released in April 8 2016. It features the Maxwell 2.0 architecture. The core clock ranges from 1140 MHz to 1165 MHz. It has 2048 shading units. The thermal design power (TDP) is 150W. Manufactured using 28 nm process technology. G3D Mark benchmark score: 7,915 points.

AMD

Radeon RX 6400

The Radeon RX 6400 is manufactured by AMD. It was released in January 19 2022. It features the RDNA 2.0 architecture. The core clock ranges from 1923 MHz to 2321 MHz. It has 768 shading units. The thermal design power (TDP) is 53W. Manufactured using 6 nm process technology. It features 12 dedicated ray tracing cores for enhanced lighting effects. G3D Mark benchmark score: 7,728 points. Launch price was $159.

Graphics Performance

The Quadro M5500 scores 7,915 and the Radeon RX 6400 reaches 7,728 in the G3D Mark benchmark — just a 2.4% difference, making them near-identical in rasterization performance. The Quadro M5500 is built on Maxwell 2.0 while the Radeon RX 6400 uses RDNA 2.0, both on 28 nm vs 6 nm. Shader units: 2,048 (Quadro M5500) vs 768 (Radeon RX 6400). Raw compute: 4.772 TFLOPS (Quadro M5500) vs 3.565 TFLOPS (Radeon RX 6400). Boost clocks: 1165 MHz vs 2321 MHz.

FeatureQuadro M5500Radeon RX 6400
G3D Mark Score
7,915+2%
7,728
Architecture
Maxwell 2.0
RDNA 2.0
Process Node
28 nm
6 nm
Shading Units
2048+167%
768
Compute (TFLOPS)
4.772 TFLOPS+34%
3.565 TFLOPS
Boost Clock
1165 MHz
2321 MHz+99%
ROPs
64+100%
32
TMUs
128+167%
48
L1 Cache
768 KB+200%
256 KB
L2 Cache
2 MB+100%
1 MB

Advanced Features (DLSS/FSR)

A critical advantage for the Radeon RX 6400 is support for FSR Frame Generation + AFMF. This allows it to generate entire frames using AI/Algorithms, essentially doubling the frame rate in CPU-bound scenarios or heavy ray-tracing titles. The Quadro M5500 lacks specific hardware/driver support for this native frame generation tier.

FeatureQuadro M5500Radeon RX 6400
Upscaling Tech
Upscaling support
FSR 3
Frame Generation
Not Supported
FSR Frame Generation + AFMF
Ray Reconstruction
No
No
Low Latency
Standard
AMD Anti-Lag
💾

Video Memory (VRAM)

The Quadro M5500 comes with 8 GB of VRAM, while the Radeon RX 6400 has 4 GB. The Quadro M5500 offers 100% more capacity, crucial for higher resolutions and texture-heavy games. Bus width: 256-bit vs 64-bit. L2 Cache: 2 MB (Quadro M5500) vs 1 MB (Radeon RX 6400) — the Quadro M5500 has significantly larger on-die cache to reduce VRAM reliance.

FeatureQuadro M5500Radeon RX 6400
VRAM Capacity
8 GB+100%
4 GB
Memory Type
GDDR6
GDDR6
Bus Width
256-bit+300%
64-bit
L2 Cache
2 MB+100%
1 MB
🖥️

Display & API Support

DirectX support: 12 (12_1) (Quadro M5500) vs 12.2 (Radeon RX 6400). Vulkan: 1.2 vs 1.3. OpenGL: 4.6 vs 4.6. Maximum simultaneous displays: 4 vs 2.

FeatureQuadro M5500Radeon RX 6400
DirectX
12 (12_1)
12.2+2%
Vulkan
1.2
1.3+8%
OpenGL
4.6
4.6
Max Displays
4+100%
2
🎬

Media & Encoding

Hardware encoder: NVENC (Maxwell) (Quadro M5500) vs None (Radeon RX 6400). Decoder: NVDEC (Maxwell) vs VCN 3.0 (Limited). Supported codecs: H.264,H.265,VP9,MPEG-2,VC-1 (Quadro M5500) vs MPEG-2,H.264 (Decode),HEVC (Decode) (Radeon RX 6400).

FeatureQuadro M5500Radeon RX 6400
Encoder
NVENC (Maxwell)
None
Decoder
NVDEC (Maxwell)
VCN 3.0 (Limited)
Codecs
H.264,H.265,VP9,MPEG-2,VC-1
MPEG-2,H.264 (Decode),HEVC (Decode)
🔌

Power & Dimensions

The Quadro M5500 draws 150W versus the Radeon RX 6400's 53W — a 95.6% difference. The Radeon RX 6400 is more power-efficient. Recommended PSU: 350W (Quadro M5500) vs 350W (Radeon RX 6400). Power connectors: PCIe-powered vs None. Card length: 0mm vs 172mm, occupying 0 vs 1 slots. Typical load temperature: 85 vs 75°C.

FeatureQuadro M5500Radeon RX 6400
TDP
150W
53W-65%
Recommended PSU
350W
350W
Power Connector
PCIe-powered
None
Length
0mm
172mm
Height
0mm
112mm
Slots
0-100%
1
Temp (Load)
85
75°C-12%
Perf/Watt
52.8
145.8+176%
💰

Value Analysis

The Quadro M5500 launched at $800 MSRP, while the Radeon RX 6400 launched at $159. The Radeon RX 6400 costs 80.1% less ($641 savings) on MSRP. Performance per dollar on MSRP (G3D Mark / MSRP): 9.9 (Quadro M5500) vs 48.6 (Radeon RX 6400) — the Radeon RX 6400 offers 390.9% better value. The Radeon RX 6400 is the newer GPU (2022 vs 2016).

FeatureQuadro M5500Radeon RX 6400
MSRP
$800
$159-80%
Performance per Dollar
9.9
48.6+391%
Codename
GM204
Navi 24
Release
April 8 2016
January 19 2022
Ranking
#321
#330