Quadro P4000 vs Radeon Instinct MI60

NVIDIA

Quadro P4000

2017Core: 1202 MHzBoost: 1480 MHz

Popular choices:

VS
AMD

Radeon Instinct MI60

2018Core: 1200 MHzBoost: 1800 MHz

Popular choices:

Performance Spectrum - GPU

About G3D Mark

G3D Mark is a standard benchmark that measures graphics performance in real-world gaming scenarios. It simplifies comparing cards from different brands, where higher scores directly correlate with better fps and smoother gaming experiences.

Head-to-Head Verdict, Benchmarks, Value & Long-Term Outlook

This comparison brings together gaming FPS, raw graphics performance, VRAM, feature set, power efficiency, pricing context, and long-term value so you can see which GPU actually makes more sense.

Quadro P4000

2017

Why buy it

  • Costs $5,185 less on MSRP ($815 MSRP vs $6,000 MSRP).
  • Delivers 623.1% more G3D Mark for each dollar spent, at 14.0 vs 1.9 G3D/$ ($815 MSRP vs $6,000 MSRP).
  • Draws 105W instead of 300W, a 195W reduction.
  • Measures 241mm instead of 267mm, a 26mm shorter card that is more SFF-friendly.

Trade-offs

  • Lower average FPS than Radeon Instinct MI60 across 50 tracked games in our benchmark data.
  • Poor future-proofing: 2017-era hardware with 8 GB of VRAM is already a legacy-tier option for modern games.

Radeon Instinct MI60

2018

Why buy it

  • 25.2% more average FPS across 50 tracked games in our benchmark data.
  • Less risky long-term buy than Quadro P4000: it remains the more sensible modern option while Quadro P4000 is already legacy-tier future-proofing.
  • More future proof: GCN 5.1 (2018−2022) on 7nm with a newer platform for upcoming games.

Trade-offs

  • Limited future-proofing: older hardware, 8 GB of VRAM, and weaker feature support mean it will age faster in upcoming AAA games.
  • 636.2% HIGHER MSRP
    $6,000 MSRPvs$815 MSRP
  • Lower G3D Mark per dollar, at 1.9 vs 14.0 G3D/$ ($6,000 MSRP vs $815 MSRP).
  • 185.7% higher power demand at 300W vs 105W.
  • 10.8% longer card at 267mm vs 241mm.

Quick Answers

So, is Radeon Instinct MI60 better than Quadro P4000?
Yes. Radeon Instinct MI60 is the better GPU overall here. You are getting 25.2% more average FPS across 50 tracked games in our benchmark data and 1.8% higher PassMark G3D performance. It also comes from 2018 instead of 2017, which helps its case as the more complete modern gaming card.
Which one is more future-proof for 2026 and beyond?
Radeon Instinct MI60 is the more future-proof choice for 2026 and beyond. You are getting a newer 2018 generation instead of 2017, better upscaling support with FSR Upscaling / FSR 4 (2025) instead of no meaningful modern upscaling stack, and a 7nm process instead of 16nm. That broader feature stack should age better as more games lean on modern upscaling and frame-generation support.
Which one is the smarter buy today, not just the cheaper card?
Radeon Instinct MI60 is the smarter buy by a wide margin. Radeon Instinct MI60 is about 636.2% more expensive on MSRP at $6,000 MSRP versus $815 MSRP, and you are getting 25.2% more estimated average FPS across 50 tracked games in our benchmark data and 1.8% higher G3D Mark. Quadro P4000 really only makes sense now as a very cheap stopgap or a used-market placeholder.
Is Quadro P4000 still worth buying for gaming in 2026?
No, not for a fresh gaming build. Quadro P4000 is 2017 hardware with 8 GB of VRAM, 11,431 in G3D Mark, and no meaningful modern upscaling stack. That is simply too far behind to be an easy modern recommendation.

Games Benchmarks

Real-world benchmarks and performance projections based on comprehensive hardware analysis and comparative metrics. Values represent expected performance on High/Ultra settings at 1080p, 1440p, and 4K. Modeled using a Ryzen 7 9800X3D reference profile to minimize specific CPU bottlenecks.

Note: Performance behavior can vary per game. Specific architectures may perform better or worse depending on game engine optimizations and API implementation.

Path of Exile 2

Path of Exile 2

PresetQuadro P4000Radeon Instinct MI60
1080p
low111 FPS137 FPS
medium94 FPS117 FPS
high80 FPS101 FPS
ultra53 FPS70 FPS
1440p
low94 FPS108 FPS
medium79 FPS89 FPS
high60 FPS73 FPS
ultra39 FPS51 FPS
4K
low37 FPS50 FPS
medium34 FPS43 FPS
high22 FPS33 FPS
ultra18 FPS28 FPS
Counter-Strike 2

Counter-Strike 2

PresetQuadro P4000Radeon Instinct MI60
1080p
low223 FPS316 FPS
medium190 FPS274 FPS
high146 FPS224 FPS
ultra117 FPS180 FPS
1440p
low164 FPS214 FPS
medium139 FPS185 FPS
high111 FPS159 FPS
ultra88 FPS126 FPS
4K
low96 FPS101 FPS
medium80 FPS85 FPS
high67 FPS73 FPS
ultra51 FPS56 FPS
League of Legends

League of Legends

PresetQuadro P4000Radeon Instinct MI60
1080p
low514 FPS524 FPS
medium412 FPS419 FPS
high343 FPS349 FPS
ultra257 FPS262 FPS
1440p
low386 FPS393 FPS
medium309 FPS314 FPS
high257 FPS262 FPS
ultra193 FPS196 FPS
4K
low257 FPS262 FPS
medium206 FPS209 FPS
high171 FPS175 FPS
ultra129 FPS131 FPS
Valorant

Valorant

PresetQuadro P4000Radeon Instinct MI60
1080p
low250 FPS276 FPS
medium219 FPS237 FPS
high176 FPS202 FPS
ultra147 FPS164 FPS
1440p
low191 FPS211 FPS
medium166 FPS186 FPS
high130 FPS158 FPS
ultra105 FPS126 FPS
4K
low101 FPS125 FPS
medium83 FPS108 FPS
high66 FPS85 FPS
ultra51 FPS68 FPS

Technical Specifications

Side-by-side comparison of Quadro P4000 and Radeon Instinct MI60

NVIDIA

Quadro P4000

The Quadro P4000 is manufactured by NVIDIA. It was released in February 6 2017. It features the Pascal architecture. The core clock ranges from 1202 MHz to 1480 MHz. It has 1792 shading units. The thermal design power (TDP) is 105W. Manufactured using 16 nm process technology. G3D Mark benchmark score: 11,431 points. Launch price was $815.

AMD

Radeon Instinct MI60

The Radeon Instinct MI60 is manufactured by AMD. It was released in November 18 2018. It features the GCN 5.1 architecture. The core clock ranges from 1200 MHz to 1800 MHz. It has 4096 shading units. The thermal design power (TDP) is 300W. Manufactured using 7 nm process technology. G3D Mark benchmark score: 11,638 points.

Graphics Performance

The Quadro P4000 scores 11,431 and the Radeon Instinct MI60 reaches 11,638 in the G3D Mark benchmark — just a 1.8% difference, making them near-identical in rasterization performance. The Quadro P4000 is built on Pascal while the Radeon Instinct MI60 uses GCN 5.1, both on 16 nm vs 7 nm. Shader units: 1,792 (Quadro P4000) vs 4,096 (Radeon Instinct MI60). Raw compute: 5.304 TFLOPS (Quadro P4000) vs 14.75 TFLOPS (Radeon Instinct MI60). Boost clocks: 1480 MHz vs 1800 MHz.

FeatureQuadro P4000Radeon Instinct MI60
G3D Mark Score
11,431
11,638+2%
Architecture
Pascal
GCN 5.1
Process Node
16 nm
7 nm
Shading Units
1792
4096+129%
Compute (TFLOPS)
5.304 TFLOPS
14.75 TFLOPS+178%
Boost Clock
1480 MHz
1800 MHz+22%
ROPs
64
64
TMUs
112
256+129%
L1 Cache
0.66 MB
1 MB+52%
L2 Cache
2 MB
4 MB+100%

Advanced Features (DLSS/FSR)

FeatureQuadro P4000Radeon Instinct MI60
Upscaling Tech
Upscaling support
FSR Upscaling / FSR 4
Frame Generation
Not Supported
Not Supported
Ray Reconstruction
No
No
Low Latency
Standard
AMD Anti-Lag
💾

Video Memory (VRAM)

Both cards feature 8 GB of GDDR6. Bus width: 256-bit vs 128-bit. L2 Cache: 2 MB (Quadro P4000) vs 4 MB (Radeon Instinct MI60) — the Radeon Instinct MI60 has significantly larger on-die cache to reduce VRAM reliance.

FeatureQuadro P4000Radeon Instinct MI60
VRAM Capacity
8 GB
8 GB
Memory Type
GDDR6
GDDR6
Bus Width
256-bit+100%
128-bit
L2 Cache
2 MB
4 MB+100%
🖥️

Display & API Support

DirectX support: 12.0 (Quadro P4000) vs 12.1 (Radeon Instinct MI60). Vulkan: 1.0 vs 1.3. OpenGL: 4.5 vs 4.5. Maximum simultaneous displays: 4 vs 1.

FeatureQuadro P4000Radeon Instinct MI60
DirectX
12.0
12.1
Vulkan
1.0
1.3+30%
OpenGL
4.5
4.5
Max Displays
4+300%
1
🎬

Media & Encoding

Hardware encoder: 6th Gen NVENC (Quadro P4000) vs VCE 4.1 (Radeon Instinct MI60). Decoder: PureVideo HD VP8 vs UVD 7.2. Supported codecs: MPEG-2,H.264,HEVC (Quadro P4000) vs MPEG-2,H.264,HEVC,VP9 (Radeon Instinct MI60).

FeatureQuadro P4000Radeon Instinct MI60
Encoder
6th Gen NVENC
VCE 4.1
Decoder
PureVideo HD VP8
UVD 7.2
Codecs
MPEG-2,H.264,HEVC
MPEG-2,H.264,HEVC,VP9
🔌

Power & Dimensions

The Quadro P4000 draws 105W versus the Radeon Instinct MI60's 300W — a 96.3% difference. The Quadro P4000 is more power-efficient. Recommended PSU: 500W (Quadro P4000) vs 500W (Radeon Instinct MI60). Power connectors: PCIe-powered vs PCIe-powered. Card length: 241mm vs 267mm, occupying 1 vs 2 slots. Typical load temperature: 80°C vs 85°C.

FeatureQuadro P4000Radeon Instinct MI60
TDP
105W-65%
300W
Recommended PSU
500W
500W
Power Connector
PCIe-powered
PCIe-powered
Length
241mm
267mm
Height
111mm
111mm
Slots
1-50%
2
Temp (Load)
80°C-6%
85°C
Perf/Watt
108.9+181%
38.8
💰

Value Analysis

The Quadro P4000 launched at $815 MSRP, while the Radeon Instinct MI60 launched at $6000. The Quadro P4000 costs 86.4% less ($5185 savings) on MSRP. Performance per dollar on MSRP (G3D Mark / MSRP): 14.0 (Quadro P4000) vs 1.9 (Radeon Instinct MI60) — the Quadro P4000 offers 636.8% better value. The Radeon Instinct MI60 is the newer GPU (2018 vs 2017).

FeatureQuadro P4000Radeon Instinct MI60
MSRP
$815-86%
$6000
Performance per Dollar
14.0+637%
1.9
Codename
GP104
Vega 20
Release
February 6 2017
November 18 2018
Ranking
#239
#232